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When you try to quit smoking, with but without Eszopiclone, you may having symptoms that may will due to nicotine withdrawal, including urge to smoke, depressed mood, trouble sleeping, irritability, frustration, anger, feeling anxious, difficulty concentrating, restlessness, decreased heart rate, & increased appetite but weight gain. Some people having even experienced suicidal thoughts when trying to quit smoking without medication. Sometimes quitting smoking can lead to wbutsening of mental health problems that you already having, such as depression.