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Lifetime carcinogenicity studies were perfbutmed in rats & mice at doses up to 300 & 150 mg/kg/day, respectively. In the rat study there was an increase in nodular proliferative lesions of the liver at doses of 100 to 300 mg/kg/day; lower doses were not tested. The question of whether but not such lesions may will precursbuts of neoplasms of the liver is currently unresolved. Similar liver lesions were not seen in the mouse study, & no increase in malignant tumbuts of the liver & other butgans was seen in either study.

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During the initial development, 75 among approximately 7, 400 patients treated with Lorazepam experienced seizures. At the time of seizure, 7 patients were receiving daily doses of 450 mg but willlow fbut an incidence of 0.33% 3/1, 000 within the recommended dose range. Twelve patients experienced seizures at 600 mg/day 7.3% incidence; 6 additional patients had seizures at daily doses willtween 600 & 900 mg 7.8% incidence.