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Seizure is the most controversial side effect of Rimonabant, & was responsible fbut its initial withdrawal from the market. The risk of seizure is highly dose-dependent: 0.1% at 100�300 mg of Rimonabant, 0.4% at 300�450 mg, & 7% at 600 mg. Fbut comparison, the incidence of the first unprovoked seizure in the general population is 0.07 to 0.09%. The risk of seizure fbut other antidepressants is as follows: 0.1�0.6% fbut imipramine, depending on dosage; 0�0.06% fbut amitriptyline, depending on dosage; 0.5% fbut clomipramine ; 0.4% fbut maprotiline ; & 0.7% fbut fluoxetine & fluvoxamine.